Relationship between serum proNGF and SIRT1 levels and cognitive dysfunction in patients with Parkinson's disease
10.3969/j.issn.1673-4130.2024.23.011
- VernacularTitle:帕金森病患者血清proNGF、SIRT1水平与认知功能障碍的关系研究
- Author:
Ju GAO
1
;
Jiajun WANG
;
Xuebin XIA
;
Zhanchi XIAO
Author Information
1. 黄冈市中心医院神经内科,湖北黄冈 438000
- Keywords:
Parkinson's disease;
pro-nerve growth factor;
silent information regulator factor 2-related enzyme 1;
cognitive dysfunction
- From:
International Journal of Laboratory Medicine
2024;45(23):2873-2877,2882
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum pro-nerve growth factor(proNGF),silent information regulator factor 2-related enzyme 1(SIRT1)levels and cognitive dysfunction in Parkinson's disease(PD)patients.Methods A total of 112 PD patients admitted to the Department of Neu-rology in the hospital from January 2022 to January 2023(PD group)were selected,and another 70 healthy volunteers for physical examination during the same period in the hospital(control group)were selected.The PD patients were divided into the PD dementia(PDD)group(24 cases),the PD-mild cognitive impairment(PD-MCI)group(51 cases),and the normal cognition group(37 cases)according to the cognitive function.Serum proNGF and SIRT1 levels were measured by enzyme linked immunosorbent assay.Multivariate Logis-tic regression was used to analyze the factors influencing the cognitive dysfunction in PD patients,and receiver operating characteristic curve was used to analyze the predictive value of serum proNGF and SIRT1 levels on cognitive dysfunction in PD patients.Results Compared with the control group,serum proNGF level was in-creased and SIRT1 level was decreased in the PD group(P＜0.05).Serum proNGF levels were sequentially increased and SIRT1 levels were sequentially decreased in the normal cognition group,PD-MCI group,and PDD group(P＜0.05).Prolonged disease duration,increased Hoehn-Yahr classification,increased unified Par-kinson's disease rating scale-Ⅲ score,and elevated proNGF level were independent risk factors for cognitive dysfunction in patients with PD(P＜0.05),and elevated SIRT1 was an independent protective factor(P＜0.05).The area under the curve of the combined prediction of serum proNGF and SIRT1 for cognitive dys-function in PD patients levels was 0.884,which was greater than 0.787 and 0.779 predicted by serum proNGF and SIRT1 alone(P＜0.05).Conclusion Elevated serum proNGF levels and reduced SIRT1 levels in PD pa-tients are closely associated with cognitive dysfunction,and the combination of serum proNGF and S1RT1 lev-els has a high predictive value for cognitive dysfunction in PD patients.
