Relationship between serum Sortilin,TMAO and inflammatory factors and abdominal aortic calcification in maintenance hemodialysis patients
10.3969/j.issn.1673-4130.2024.23.008
- VernacularTitle:血清Sortilin、TMAO与维持性血液透析患者炎症因子和腹主动脉钙化的关系研究
- Author:
Yang WEI
1
;
Gaiqin GAO
;
Xiaopeng YAN
;
Min YANG
Author Information
1. 铜川市人民医院肾脏内科,陕西铜川 727000
- Keywords:
maintenance hemodialysis;
sorting protein;
trimethylamine oxide;
inflammation;
ab-dominal aortic calcification
- From:
International Journal of Laboratory Medicine
2024;45(23):2856-2861
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum sorting protein(Sortilin),trimethyl-amine oxide(TMAO)and inflammatory factors and abdominal aortic calcification(AAC)in maintenance he-modialysis(MHD)patients.Methods A total of 197 MHD patients(MHD group)admitted to Department of Nephrology in the hospital from January 2021 to May 2023 and 150 physically examined healthy individuals(control group)during the same period were prospectively selected,and the MHD patients were classified into the moderate and severe AAC group(82 patients)and no or mild AAC group(115 patients)according to the AAC score.The serum of serum Sortilin,TMAO and inflammatory factors[interleukin(IL)-1β,IL-6,tumor necrosis factor-α(TNF-α)]were measured using enzyme-linked immunosorbent assay.The correlation be-tween serum Sortilin,TMAO,and inflammatory factors in MHD patients was assessed using Spearman corre-lation analysis,and influencing factors associated with moderate and severe AAC in MHD patients were ex-plored using multivariate Logistic regression analysis.The predictive value of serum Sortilin and TMAO levels for moderate and severe AAC in MHD patients was analyzed using receiver operating characteristic curve.Re-sults The levels of serum Sortilin,TMAO,IL-1β,IL-6 and TNF-α in moderate and severe AAC group were higher than those in no or mild AAC group and control group(all P＜0.05).Serum Sortilin and TMAO were positively correlated with IL-1β,IL-6 and TNF-α levels in MHD patients(all P＜0.05).Prolonged dialysis age(OR=1.034,95％CI:1.010-1.060),increased levels of IL-6(OR=1.092,95％CI:1.034-1.152),Sortilin(OR=1.076,95％CI:1.043-1.110)and TMAO(OR=1.384,95％CI:1.150-1.664)were independent risk factors for moderate and severe AAC in MHD patients(P＜0.05).The area under the curve of serum Sortilin combined with TMAO levels in predicting moderate and severe AAC in MHD patients was 0.885(95％CI:0.831-0.926),which was greater than 0.785(95％CI:0.721-0.841)and 0.797(95％CI:0.734-0.850)predicted by serum Sortilin and TMAO levels alone(P＜0.05).Conclusion The levels of se-rum Sortilin and TMAO in MHD patients are increased,and are closely related to the elevation of inflammato-ry factors and AAC.Furthermore,the combination of serum Sortilin and TMAO levels shows certain predic-tive value for moderate and severe AAC in MHD patients.
