Reference intervals of thrombin-antithrombin complex and plasmin-α2-antiplasmin complex in the elderly population in Beijing
10.3969/j.issn.1673-4130.2024.23.006
- VernacularTitle:北京地区老年人群凝血酶-抗凝血酶复合物和纤溶酶-α2纤溶酶抑制剂复合物参考区间的研究
- Author:
Lei ZHANG
1
;
Yiming CHEN
;
Hui YUAN
Author Information
1. 首都医科大学附属北京安贞医院检验科,北京 100029
- Keywords:
thrombin-antithrombin complex;
plasmin-α2-antiplasmin complex;
reference interval;
elderly population
- From:
International Journal of Laboratory Medicine
2024;45(23):2844-2848
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the levels of thrombin-antithrombin complex(TAT)and plasmin-α2-anti-plasmin complex(PIC)in the apparently healthy elderly population in Beijing,and to establish the reference intervals.Methods A total of 839 elderly individuals,including 418 males(60-＜70 year-old 141 cases,70-＜80 year-old 135 cases,≥80 year-old 142 cases)and 421 females(60-＜70 year-old 145 cases,70-＜80 year-old 140 cases,≥80 year-old 136 cases),who underwent physical examinations at the Health Management Center of Beijing Anzhen Hospital,Capital Medical University from January 1,2023 to September 30,2023,were selected.The levels of TAT and PIC in plasma were detected using Shine i2900(Guangzhou Wondfo Bio-tech Co.,Ltd.)automated chemiluminescence immune detection system and its supporting reagents.The dis-tribution among different gender and age groups was analyzed,and reference intervals were established.Results The levels of TAT in males across all age groups were lower than those in females(P＜0.01).There was no difference in the comparison results between the 60-＜70 year-old and the 70-＜80 year-old within the male and female groups,respectively.The differences between the ages of 60-＜80 year-old and ≥80 year-old in both gender groups were statistically significant(P＜0.01),and the levels showed an upward trend with age.There was no difference in the level of PIC between the male and female groups(P＞0.05),while there were differences in all age groups within the two gender groups(P＜0.01),and the trend was in-creasing with age.TAT:for males aged 60-＜80 and 80,the reference intervals were 0.69-2.42 ng/mL and 0.87-3.71 ng/mL,respectively.For females aged 60-＜80 and≥80,the reference intervals were 0.67-2.82 ng/mL and 1.00-3.66 ng/mL,respectively.PIC:for people aged 60-＜70,70-＜80,and 80 were 0.10-0.89 μg/mL,0.12-0.99 μg/mL,and 0.21-1.06 μg/mL,respectively.Conclusion There are differences in TAT and PIC among different gender and age groups in the elderly population with apparent health.This study successfully established reference interval for TAT and PIC in the elderly population with apparent health in Beijing.
