Retrospective analysis of virus antibodies related to nervous system infections in patients with cognitive impairment
10.3969/j.issn.1673-4130.2024.23.002
- VernacularTitle:认知障碍患者神经系统感染相关病毒抗体回顾性分析
- Author:
Danwei YU
1
;
Quzhen NIMA
;
Ruimin MA
;
Jie LIU
;
Miao MA
;
Guojun ZHANG
Author Information
1. 首都医科大学附属北京天坛医院实验诊断中心/北京市免疫试剂临床工程技术研究中心/国家药监局体外诊断质量控制重点实验室,北京 100070
- Keywords:
cognitive impairment;
herpes simplex virus-1;
infection burden
- From:
International Journal of Laboratory Medicine
2024;45(23):2823-2828,2833
- CountryChina
- Language:Chinese
-
Abstract:
Objective To retrospectively analyze the characteristics of viral antibodies related to nervous system infections in patients with cognitive impairment,evaluate their relationship with cognitive impairment,and explore the relationship between viral infections and the occurrence and development of cognitive impair-ment.Methods A total of 170 mild cognitive impairment patients who visited Beijing Tiantan Hospital,Cap-ital Medical University from June 2019 to June 2023 were selected as the mild cognitive impairment group,208 cognitive impairment patients were selected as the cognitive impairment group,143 dementia patients were se-lected as the dementia group,and 146 age-matched and gender-matched non infectious and non inflammatory disease controls during the same period in the hospital were selected as the control group.The levels of virus antibodies related to nervous system infections in the serum and cerebrospinal fluid of patients were detected,the detection rate and levels of antibodies were compared,and the infection burden was calculated.The cogni-tive function of all patients was evaluated and the relationship between infection burden and the degree of cog-nitive dysfunction was analyzed.Results The detection rate and antibody level of herpes simplex virus(HSV)1 IgG in the serum of three groups of patients with cognitive impairment were significantly higher than those in the control group(P＜0.05).The detection rate of HSV(1+2)IgM in the serum of three groups of pa-tients with cognitive impairment was higher than that in the control group(P＜0.05),but there was no sta-tistically significant difference between the mild cognitive impairment group,cognitive impairment group,and dementia group(P＞0.05).The serum infection load of three groups of patients with cognitive impairment was higher than that of the control group(P＜0.05),and the higher the infection load,the more severe the cognitive impairment.Conclusion Viral infection is an important influencing factor of cognitive impairment diseases,and HSV infection may be a promoting factor of cognitive dysfunction.
