Advances in the application of ginsenosides in type 2 inflammation-related diseases
10.3760/cma.j.issn.1673-4408.2025.10.010
- VernacularTitle:人参皂苷在二型炎症相关疾病中的应用进展
- Author:
Liang HU
1
;
Zuoying MA
;
Kangyi ZHANG
;
Yundong WANG
;
Qingyu WEI
Author Information
1. 长春市儿童医院过敏反应科 130051
- Keywords:
Ginsenosides;
Type 2 inflammation;
Allergic diseases
- From:
International Journal of Pediatrics
2025;52(10):694-697
- CountryChina
- Language:Chinese
-
Abstract:
Type 2 inflammation（T2 inflammation）is an immune response mediated by Th2 cells，eosinophils，type 2 innate lymphocytes，and other cells. Its pathological characteristics are manifested by the abnormally high expression of type 2 cytokines such as IL-4，IL-5，and IL-13，and it widely involves allergic diseases including asthma，allergic rhinitis，and atopic dermatitis. Ginsenosides are the core active ingredients of ginseng and the key substances for ginseng to exert its pharmacological effects. It has anti-inflammatory and immunomodulatory effects. This article reviews the mechanism of action，experimental research progress，and clinical application prospects of ginsenosides in T2 inflammation，explores the therapeutic potential and clinical challenges of ginsenosides，and proposes future research directions.
