Progress on immune evasion mechanism in chronic infection of Mycoplasma pneumoniae
10.3760/cma.j.issn.1673-4408.2025.10.008
- VernacularTitle:肺炎支原体慢性感染中免疫逃逸机制的研究进展
- Author:
Ning ZHANG
1
;
Yingxue ZOU
Author Information
1. 天津市儿童医院（天津大学儿童医院）马场院区呼吸科 300074
- Keywords:
Mycoplasma pneumoniae;
Immune evasion;
Chronic infection;
Antigenic variation;
Biofilm
- From:
International Journal of Pediatrics
2025;52(10):685-688
- CountryChina
- Language:Chinese
-
Abstract:
Mycoplasma pneumoniae（MP）is a cell wall-deficient pathogen positioned between viruses and bacteria，possessing a small genome undergoing continuous reduction and primarily transmitted via droplets. MP infection typically manifests as an acute process，inducing a series of immune responses in the host. However，some pediatric patients experience prolonged or recurrent infections following acute episodes，suggesting incomplete clearance of MP by the host and the pathogen evasion from immune surveillance through specific mechanisms，leading to chronic infection. In recent years，increasing research has revealed the immune evasion strategies enabling MP's long-term survival within the host. This review summarizes recent domestic and international advances in studying immune evasion mechanisms during chronic MP infection，aiming to provide reference for clinical diagnosis and treatment.
