Progress on the role of carboxyhemoglobin in neonatal hemolytic jaundice accompanied with myocardial injury
10.3760/cma.j.issn.1673-4408.2025.10.007
- VernacularTitle:碳氧血红蛋白在新生儿溶血性黄疸并发心肌损害中的作用研究进展
- Author:
Xin QING
1
;
Jimo ZHU
;
Yu LUO
;
Binzhi TANG
Author Information
1. 电子科技大学医学院，成都 610054
- Keywords:
Jaundice;
Hemolysis;
Carboxyhemoglobin;
Myocardial injury;
Neonates
- From:
International Journal of Pediatrics
2025;52(10):681-684
- CountryChina
- Language:Chinese
-
Abstract:
Neonatal jaundice is commonly seen in early postnatal days，and is partly caused by hemolysis. It has been found that hemolytic jaundice in neonates is often accompanied with myocardial injury，which may pose a threat to their health. However，the pathogenic mechanism remains unclear. This review focuses on the potential mechanisms of myocardial injury associated with hemolytic jaundice，particularly highlighting the role of carboxyhemoglobin（COHb）as a potential contributor. Emerging evidence suggests that COHb，a hemolytic metabolite，can cause myocardial injury through mechanisms such as influencing oxygen metabolism and exerting cytotoxic effects，particularly in neonates who are susceptible to hypoxia. The review aims to summarize the latest research progress in this field，to facilitate early prediction，early detection，and timely intervention for hemolytic jaundice accompanied with myocardial injury，while providing novel therapeutic strategies and targets.
