Progress on the role of heat shock proteins and cell apoptosis in inflammatory bowel disease
10.3760/cma.j.issn.1673-4408.2025.10.004
- VernacularTitle:热休克蛋白与细胞凋亡在炎症性肠病中的作用研究进展
- Author:
Junye DU
1
;
Xiaolin YE
;
Tianzhuo ZHANG
;
Jie WU
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院消化科 100045
- Keywords:
Heat shock protein;
Apoptosis;
Inflammatory bowel disease;
Treatment strategy
- From:
International Journal of Pediatrics
2025;52(10):665-670
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease（IBD）is a type of disease characterized by chronic intestinal inflammation，mainly including Crohn's disease，ulcerative colitis，and undifferentiated IBD. Its pathogenesis is very complex and involves multiple factors. In recent years，studies have shown that heat shock proteins（HSPs）and cell apoptosis play important roles in the occurrence and progression of IBD. HSPs not only participate in cellular stress response，but also play a crucial role in regulating cell apoptosis. The specific mechanism of the interaction between HSPs and apoptosis in IBD is currently unclear. This article reviews the relationship and mechanism between HSPs and apoptosis in the occurrence and development of IBD，explores the roles of HSPs and apoptosis in IBD，and proposes potential treatment strategies to provide more effective treatment options for IBD patients in the future.
