Attach importance to the diagnosis and treatment of crystalline nephropathies in children
10.3760/cma.j.issn.1673-4408.2025.10.001
- VernacularTitle:重视儿童晶体性肾病的诊治
- Author:
Wenyan HUANG
1
;
Yangyang JIAO
Author Information
1. 上海市儿童医院 上海交通大学医学院附属儿童医院肾脏风湿免疫科 200062
- Keywords:
Children;
Crystalline nephropathies;
Acute kidney injury;
Chronic kidney disease;
Renal tubulointerstium
- From:
International Journal of Pediatrics
2025;52(10):647-652
- CountryChina
- Language:Chinese
-
Abstract:
Crystalline nephropathy is a kidney disorder characterized by crystal deposition in the renal tubules and interstitium，leading to renal dysfunction. Clinical manifestations include polydipsia，polyuria，renal function abnormalities，with or without crystalluria. The pathogenesis involves direct and indirect cytotoxicity caused by crystal deposition，inflammatory kidney injury，tubular obstruction，oxidative stress and inflammatory responses，which further promote renal fibrosis. It represents a significant cause of both acute and chronic renal failure. In adults，it is primarily induced by medications and secondary factors，while it is relatively rare and mainly caused by genetic and metabolic disorders in children. Diagnosis relies on clinical presentation，urinalysis，and medical imaging，while confirmatory diagnosis requires renal biopsy. Currently，due to the limitid awareness of pediatric crystalline nephropathy，it is essential to enhance pediatrician' understanding of this disease for early and precise diagnosis and treatment，thereby improving prognosis and reducing the risk of end-stage renal disease.
