Trends in the global burden of neonatal infections from 1990 to 2021: Joinpoint regression analysis based on the GBD database
10.3760/cma.j.issn.1673-4408.2025.09.012
- VernacularTitle:1990年至2021年新生儿感染全球负担变化趋势：基于GBD数据库的Joinpoint回归分析
- Author:
Yu DAI
1
;
Shushu LI
;
Xiaohui CHEN
;
Shuping HAN
;
Li SHA
Author Information
1. 南京医科大学附属妇产医院（南京市妇幼保健院）儿科 210004
- Keywords:
Neonatal sepsis;
Neonatal infections;
Global burden of disease;
Trends
- From:
International Journal of Pediatrics
2025;52(9):634-639
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the global disease burden of neonatal sepsis and other neonatal infections（NSNIs），providing scientific basis for their prevention and control.Methods:Using the Global Burden of Disease（GBD）2021 database，this article calculated the incidence，mortality，and age-standardized rates for NSNIs. Trends were evaluated with Joinpoint regression model，and compared at different socio-demographic index（SDI）levels.Results:From 1990 to 2021，the global age-standardized incidence rate（ASIR）of NSNIs decreased from 78.98 to 62.70 per 100 000 with an with average annual percentage change（AAPC）of -0.73%（ P<0.01）. The age-standardized mortality rate（ASMR）declined from 4.77 to 3.76 per 100 000 with an AAPC of -0.76%（ P<0.01）. In particular，the disease burden was consistently higher among male neonates. Low birth weight was the primary risk factor globally，followed by preterm birth. Regions with lower SDI levels exhibited higher ASIR and ASMR，and household solid fuel air pollution contributed more to NSNIs-related mortality. Conclusion:Although the overall disease burden of NSNIs has declined，male neonates and low-SDI regions still face substantial challenges. Continuous efforts to improve air quality are warranted，and low-SDI regions should further strengthen healthcare infrastructure to enhance diagnostic and treatment quality.
