Progress on 4-HNE in pulmonary diseases
10.3760/cma.j.issn.1673-4408.2025.09.009
- VernacularTitle:4-羟基壬烯醛在肺部疾病中的研究进展
- Author:
Weiling XU
1
;
Shaofei YU
;
Hua ZHU
Author Information
1. 内蒙古医科大学，呼和浩特 010110
- Keywords:
Pulmonary diseases;
4-HNE;
Oxidative stress;
Active aldehydes
- From:
International Journal of Pediatrics
2025;52(9):619-623
- CountryChina
- Language:Chinese
-
Abstract:
4-hydroxynonenal（4-HNE），an oxidative stress-induced lipid peroxidation product，is generated through free radical chain reactions of polyunsaturated fatty acid（PUFA）under oxidative stress conditions. Current studies suggest that excessive accumulation of 4-HNE in the body drives the progression of various pulmonary diseases，involving trauma，infection，asthma，autoimmune diseases，etc. It not only serves as a biomarker for assessing the severity of lung diseases，but also provides a theoretical foundation for developing novel therapeutic strategies by modulating aldehyde-metabolizing enzymes or targeting ferroptosis pathways. This review summarizes the biological effects of 4-HNE and its association with pulmonary diseases.Deep exploration of its expression mechanisms in lung pathologies are expected to advance precision diagnosis and treatment for respiratory system disorders.
