Progress on ferroptosis in bronchial asthma
10.3760/cma.j.issn.1673-4408.2025.09.005
- VernacularTitle:铁死亡在支气管哮喘中的研究进展
- Author:
Qingwen FAN
1
;
Xiangrong ZHENG
Author Information
1. 中南大学湘雅医院儿童医学中心，长沙 410008
- Keywords:
Ferroptosis;
Asthma;
Airway inflammation;
Lipid peroxidation
- From:
International Journal of Pediatrics
2025;52(9):598-602
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a novel form of cell death that has garnered increasing attention in various diseases，including bronchial asthma（referred to as asthma），in recent years. The mechanism of ferroptosis is closely related to the accumulation of iron ions，the production of reactive oxygen species，and lipid peroxidation，while it is also precisely regulated by the body's antioxidant system. In asthma，ferroptosis may exacerbate airway epithelial cell damage and affect immune cell function and the release of inflammatory factors by influencing key pathophysiological processes such as airway remodeling and inflammation，thereby impacting the immune response in asthma. Although the specific mechanisms of ferroptosis in asthma are not yet fully understood，recent studies have indicated that inhibiting ferroptosis can improve airway inflammation in animal models of asthma. This study will elucidate the mechanisms of ferroptosis and its relationship with asthma，providing new insights for the treatment of asthma.
