Progress on clinical effects and underlying mechanisms of catecholamines in neuroblastoma
10.3760/cma.j.issn.1673-4408.2025.09.003
- VernacularTitle:儿茶酚胺在神经母细胞瘤中的临床作用及机制研究进展
- Author:
Yinfeng ZHANG
1
;
Qian LI
;
Yijin GAO
Author Information
1. 上海交通大学医学院附属上海儿童医学中心儿科医学转化研究所 200127
- Keywords:
Neuroblastoma;
Catecholamines;
Posttranslational modifications;
Dopaminylation
- From:
International Journal of Pediatrics
2025;52(9):588-592
- CountryChina
- Language:Chinese
-
Abstract:
Neuroblastoma is a common extracranial solid tumors in children，and patients with high-risk disease have poor prognosis. Since the pathogenesis of neuroblastoma has not been fully elucidated，early diagnosis and timely，effective clinical intervention are key strategies to improve survival in affected children. As a neuroendocrine tumor，neuroblastoma is characterized by abnormal secretion of catecholamine compounds，the synthesis and release of which are closely associated with both diagnosis and prognosis. This review summarizes the biosynthetic and metabolic pathways of catecholamines and their clinical applications in neuroblastoma，and further discusses the molecular mechanisms by which catecholamines contribute to neuroblastoma progression.
