Advances in metabolomics of respiratory syncytial virus infection in children
10.3760/cma.j.issn.1673-4408.2025.08.003
- VernacularTitle:代谢组学在儿童呼吸道合胞病毒感染中的研究进展
- Author:
Xiao LONG
1
;
Yu DENG
;
Na ZANG
;
Enmei LIU
Author Information
1. 重庆医科大学附属儿童医院呼吸科 国家儿童健康与疾病临床医学研究中心 儿童发育疾病研究教育部重点实验室 儿童感染与免疫罕见病重庆市重点实验室 400014
- Keywords:
Children;
Metabolomics;
Respiratory syncytial virus;
Asthma
- From:
International Journal of Pediatrics
2025;52(8):515-519
- CountryChina
- Language:Chinese
-
Abstract:
Respiratory syncytial virus is the leading pathogen of lower respiratory tract infections in children under 5 years of age. Early-life respiratory syncytial virus infection is closely associated with long-term adverse outcomes，including impaired lung function，recurrent wheezing，and asthma. Metabolomics，an emerging systems biology approach，enables the quantitative analysis of dynamic changes in small-molecule metabolites within biological samples，providing critical insights into disease pathogenesis. This article reviews the metabolomic profiles of children with respiratory syncytial virus infection，with a focus on alterations in carbohydrate，lipid，and amino acid metabolism pathways. Additionally，it examines the distinct metabolomic features of children who develop recurrent wheezing following respiratory syncytial virus infection. These findings offer novel perspectives for elucidating the pathophysiological mechanisms of respiratory syncytial virus infection and improving early diagnosis and prognostic assessment.
