Progress on the endocytosis of glomerular podocytes
10.3760/cma.j.issn.1673-4408.2025.07.009
- VernacularTitle:肾小球足细胞内吞的研究进展
- Author:
Lihui PENG
1
;
Yulin KANG
Author Information
1. 上海市儿童医院 上海交通大学医学院附属儿童医院肾脏风湿科 200062
- Keywords:
Glomerulus;
Podocyte;
Endocytosis;
Cytoskeleton;
Oxidative stress
- From:
International Journal of Pediatrics
2025;52(7):471-475
- CountryChina
- Language:Chinese
-
Abstract:
Proteinuria is a common manifestation of primary nephrotic syndrome in children and attributed to podocyte injury. Endocytosis is a biological process for maintaining podocyte function through the internalization and recycling of extracellular material and plasma membrane components. Recently，it has been found that podocyte endocytosis is regulated by podocyte membrane proteins as well as actin cytoskeleton. Endocytosis defects affect the signaling pathways of some podocytes. Protein expression in the slit diaphragm of podocytes is regulated by the actin-dependent endocytic pathway. Studying podocyte endocytosis helps to understand the pathogenesis of proteinuria in chronic kidney disease and provide potential therapeutic targets for glomerular disease.
