Advances in endothelial glycocalyx in rheumatic and immune diseases
10.3760/cma.j.issn.1673-4408.2025.07.007
- VernacularTitle:内皮糖萼在风湿免疫性疾病中的研究进展
- Author:
Qianjun CHEN
1
;
Weijie LI
;
Jing XIE
;
Lintao WEN
;
Ronghao ZHENG
Author Information
1. 湖北医药学院 湖北省妇幼保健院培养基地，武汉 430070
- Keywords:
Endothelial glycocalyx;
Rheumatic and immune diseases;
Inflammation
- From:
International Journal of Pediatrics
2025;52(7):461-465
- CountryChina
- Language:Chinese
-
Abstract:
The endothelial glycocalyx（EG）is a villous polyglycoprotein complex that covers the apical membrane of endothelial cells，situated between the blood vessel wall and the bloodstream.Due to its unique physiological position，the EG plays a crucial role in vascular permeability，mechanical conduction，coagulation，inflammation，and other processes.EG injury can cause endothelial barrier dysfunction，increase vascular permeability，and promote inflammation and thrombosis.Recent studies have revealed that the involvement of EG in inflammatory responses may contribute significantly to the pathogenesis of certain rheumatic and immune diseases as well as multi-system inflammatory syndrome，Kawasaki disease，rheumatoid arthritis，systemic lupus erythematosus and antiphospholipid syndrome，etc.This review paper aims to provide an overview of the structure and function of EG while highlighting its research progress in diagnosing and treating rheumatic and immune diseases.
