Advances in the role of gut microbiota-drived short-chain fatty acids in autoimmune diseases in children
10.3760/cma.j.issn.1673-4408.2025.07.006
- VernacularTitle:肠道菌群来源的短链脂肪酸在儿童自身免疫性疾病中的作用研究进展
- Author:
Zuxiong GAO
1
;
Chuyue SU
;
Zhenzheng CAO
;
Rong JIAO
Author Information
1. 湖北医药学院附属襄阳市第一人民医院儿科 441000
- Keywords:
Children;
Short-chain fatty acids;
Autoimmune diseases;
Gut microbiota
- From:
International Journal of Pediatrics
2025;52(7):456-460
- CountryChina
- Language:Chinese
-
Abstract:
Alterations in the gut microbiota can lead to the occurrence of autoimmune diseases and affect the immune system through various metabolic pathways，ultimately causing damage to target organs. Short-chain fatty acids（SCFAs），the common metabolic product of the gut microbiota，are closely related to the functions of multiple organs and diseases. An increasing number of studies have shown that SCFAs can regulate the immune response of the body and influence the immune process of various autoimmune diseases. However，there are relatively few domestic studies on the relationship between SCFAs and autoimmune diseases in childhood. This article aims to explore the role of SCFAs in various common autoimmune diseases in childhood and summarize the alleviation of clinical manifestations in children with various autoimmune diseases by SCFAs，providing research ideas for exploring the pathogenesis of various autoimmune diseases，and enrich the theoretical basis for conducting fecal microbiota transplantation therapy.
