Advances in the clinical application of high-flow nasal cannula oxygen therapy in pediatric acute respiratory distress syndrome
10.3760/cma.j.issn.1673-4408.2025.07.002
- VernacularTitle:经鼻高流量氧疗在儿童急性呼吸窘迫综合征的临床应用进展
- Author:
Le JING
1
;
Hongjun MIAO
Author Information
1. 南京医科大学儿科学院 210005
- Keywords:
Pediatric acute respiratory distress syndrome;
High-flow nasal cannula oxygen therapy;
ROX index
- From:
International Journal of Pediatrics
2025;52(7):436-440
- CountryChina
- Language:Chinese
-
Abstract:
Pediatric acute respiratory distress syndrome（PARDS）in children is one of the critical illnesses，with a high mortality rate. It is a pulmonary inflammatory response syndrome mediated by multiple pro-inflammatory factors caused by various etiologies，characterized by diffuse lung injury and infiltrative pulmonary edema caused by noncardiogenic factors in the lungs and outside the lungs. The Second Pediatric Acute Lung Injury Consensus Conference in 2023 updated the definition of PARDS，which can be classified as mild/moderate and severe cases according to the severity of the condition，and promoted the application of new high-flow nasal cannula oxygen therapy. High-flow nasal oxygen cannula therapy has been widely used in the respiratory support therapy of mild to moderate PARDS. This article provides a review of the therapeutic mechanism，application timing，commonly used efficacy evaluation methods，sequential oxygen therapy after mechanical ventilation and limitations of nasal high-flow nasal cannula oxygen therapy in PARDS，providing a basis for the use of high-flow oxygen therapy in such children.
