Advances in IP-10 and its genetic polymorphisms in relation to Kawasaki disease

VernacularTitle:γ干扰素诱导蛋白10及其基因多态性与川崎病相关研究进展
Author: Meng WANG ¹ ; Yanyan LIANG ; Wanyu FENG ; Xuewen SU ; Hua ZHU
Author Information

1. 内蒙古医科大学，呼和浩特　010020
Keywords: Kawasaki disease; IP-10; IP-10 gene; Chemokine
From: International Journal of Pediatrics 2025;52(6):405-409
CountryChina
Language:Chinese
Abstract: Kawasaki disease（KD）is an acute systemic vasculitis primarily affecting small- and medium-sized arteries in children，with widespread inflammation as the major pathological hallmark. A subset of patients with KD exhibit resistance to high-dose intravenous immunoglobulin（IVIG）therapy，which significantly increases the risk of developing severe cardiovascular complications，particularly coronary artery lesions（CAL）. Interferon gamma-inducible protein 10（IP-10），a chemokine，exerts its biological functions by binding to its specific receptor，chemokine receptor 3（CXCR3）. In the relevant research on KD，the association between IP-10 and IP-10 gene polymorphism with KD has garnered significant attention from both domestic and international researchers. This article reviews the recent research progress on the relationship between IP-10，its gene polymorphism and KD，with the aim of providing references for the pathogenesis，prevention，treatment and prognosis of KD.