Advance in the application of non-invasive examinations for monitoring disease activity in pediatric Crohn's disease
10.3760/cma.j.issn.1673-4408.2025.06.005
- VernacularTitle:非侵入性检查在儿童克罗恩病活动度监测中的应用进展
- Author:
Mingyu ZHANG
1
;
Lingfen XU
Author Information
1. 中国医科大学附属盛京医院小儿消化内科，沈阳 110004
- Keywords:
Crohn's disease;
Non-invasive;
Activity monitoring;
Children
- From:
International Journal of Pediatrics
2025;52(6):381-384
- CountryChina
- Language:Chinese
-
Abstract:
Crohn's disease（CD）is a chronic non-specific inflammatory bowel disease with unclear etiology and pathogenesis. Endoscopy combined with pathological examination remains the gold standard for diagnosing and monitoring CD activity. However，endoscopy is limited to the mucosal surface and intestinal lumen，making it difficult to assess the full thickness of the intestinal wall and extraintestinal conditions，and it cannot reach the proximal end of a narrowed intestinal segment. Additionally，endoscopic biopsy is invasive，requires thorough bowel preparation，and is poorly tolerated by infants and young children.This article reviews recent research advances in non-invasive examination methods for CD patients，including non-invasive biomarkers in blood and stool，as well as non-invasive imaging techniques，and their potential applications in the diagnosis and treatment of CD. By integrating these biomarkers with clinical parameters，it is possible to reduce reliance on invasive testing，optimize personalized treatment strategies，and enable early identification of disease activity and remission status. This comprehensive approach allows for more accurate assessment of disease progression，adjustment of treatment plans，and the delivery of more precise and individualized care for CD patients，ultimately improving their prognosis and quality of life.
