Advances in diagnosis and treatment of primary renal tubular acidosis in children and key points of disease management
10.3760/cma.j.issn.1673-4408.2025.06.002
- VernacularTitle:儿童原发性肾小管酸中毒的诊治进展及管理要点
- Author:
Chaoying CHEN
1
;
Xiaoyan PENG
Author Information
1. 首都医科大学附属首都儿童医学中心肾脏内科，北京 100020
- Keywords:
Children;
Renal tubular acidosis，primary;
Diagnostic and therapeutic advances;
Disease management
- From:
International Journal of Pediatrics
2025;52(6):364-370
- CountryChina
- Language:Chinese
-
Abstract:
Renal tubular acidosis（RTA）in children is mainly primary，with a low incidence rate and often an insidious onset. It exhibits strong clinical heterogeneity，and the related complications include growth retardation，abnormal bone metabolism，and renal dysfunction，which seriously affect the life quality of children. Currently，clinical attention to RTA remains insufficient，and its genetic mechanisms have not been fully clarified. The metabolic control rate and patient compliance need to be improved. This article reviews important research advances in the field of primary RTA，summarizes progress in classification，etiology，diagnostic and therapeutic strategies，prognosis and long-term disease management. It emphasizes that the precise diagnosis and treatment of children with primary RTA require the integration of molecular genetic technologies，individualized treatment regimens，and long-term monitoring and follow-up. In the future，efforts should focus on enhancing epidemiological studies and establishing evidence-based guidelines，further elucidating the pathogenesis of RTA，developing better-tolerated medications suitable for long-term use，and advancing parallel strategies for the prevention and management of primary RTA.
