Progress on the role of intestinal flora in neuropsychiatric disorders in children
10.3760/cma.j.issn.1673-4408.2025.05.011
- VernacularTitle:肠道菌群在儿童神经精神系统疾病中作用机制的研究进展
- Author:
Chunzhu PAN
1
;
Wenjin GENG
Author Information
1. 河北省儿童医院急诊科，石家庄 050031
- Keywords:
Children;
Intestinal flora;
Microbiota-gut-brain axis;
Neuropsychiatric disorders
- From:
International Journal of Pediatrics
2025;52(5):338-342
- CountryChina
- Language:Chinese
-
Abstract:
With the development of gene sequencing technology and the further understanding of the microbiota-gut-brain axis（MGBA）mechanism，the research on the intestinal flora has been increasing. As one ages，the intestinal microecology gradually maintains a dynamic balance. The MGBA plays an important role in the connection between the brain and the intestine，and the intestinal flora can directly or indirectly affect the MGBA through neural，neuroendocrine，and neuroimmune pathways，thereby influencing brain function. Currently，the relationship between the intestinal flora and neuropsychiatric disorders in children is increasingly becoming a new hotspot. The main diseases include autism spectrum disorder，epilepsy，attention deficit hyperactivity disorder，and depression，etc. This article mainly reviews the research progress on the mechanism of the intestinal flora in neuropsychiatric disorders in children and the relationships between them，in order to provide new ideas and methods for the clinical treatment and research of neuropsychiatric disorders in children.
