Advance in correlation between ITGA2 gene and disease
10.3760/cma.j.issn.1673-4408.2025.05.010
- VernacularTitle:ITGA2基因与疾病相关性研究进展
- Author:
Yuan HOU
1
;
Yanyan LIANG
;
Wanyu FENG
;
Ruhan YI
;
Hua ZHU
Author Information
1. 内蒙古医科大学，呼和浩特 010020
- Keywords:
ITGA2 gene;
Disease correlation;
Integrin
- From:
International Journal of Pediatrics
2025;52(5):334-337
- CountryChina
- Language:Chinese
-
Abstract:
The integrin alpha 2（ITGA2）gene locates on chromosome 5q11.2，encodes the α 2 subunit of the integrin family.The α 2 subunit is found on many cell surfaces.The α 2 subunit plays an important role in the regulation of platelet aggregation，cell migration，cell proliferation and angiogenesis.Through a wide range of studies conducted in recent years，researchers have discovered that this gene is linked to some diseases，such as rheumatoid arthritis，pediatric sickle cell disease，Kawasaki disease，malignant tumor and biliary atresia.These studies have contributed to the early identification of diseases associated with this gene and the exploration of diagnostic and therapeutic solutions for them.This article reviews the advancements in research concerning the association of ITGA2 gene with various diseases.
