Advance in the genetics of self-limiting epilepsy syndrome in children
10.3760/cma.j.issn.1673-4408.2025.05.008
- VernacularTitle:儿童自限性癫痫综合征的遗传学研究进展
- Author:
Shangyu WANG
1
;
Hongdan QI
;
Xin WANG
;
Bing WU
;
Gang ZHANG
Author Information
1. 南京医科大学附属儿童医院神经内科 210093
- Keywords:
Children;
Self-limiting epilepsy syndrome;
Genetics;
Prognosis;
Precision therapy
- From:
International Journal of Pediatrics
2025;52(5):325-329
- CountryChina
- Language:Chinese
-
Abstract:
Self-limiting epilepsy syndrome（SeLES）can be classified into two types based on age of onset：one occurring in the neonatal to infant period and the other in the childhood period.These diseases can exhibit complete remission within a specific age range，or be completely controlled with anti-seizure drugs.Children with SeLES typically have normal cognition or only mild cognitive impairment.In recent years，advancements in genetic testing technology have led to a better understanding of the genetic etiologies of SeLES，offering more possibilities for precision treatment.This article aims to explore the role of genetic factors in SeLES，providing reference for the diagnosis，precise drug selection，and prognosis of this type of hereditary epilepsy syndrome，in order to provide theoretical support for the long-term management of patients，and improve their quality of life.
