Progress on the role of intestinal flora metabolite butyrate in primary nephrotic syndrome
10.3760/cma.j.issn.1673-4408.2025.05.002
- VernacularTitle:肠道菌群代谢物丁酸盐在原发性肾病综合征中的作用
- Author:
Xingyu YU
1
;
Wenyan HUANG
Author Information
1. 上海交通大学医学院附属儿童医院肾脏风湿免疫科 200062
- Keywords:
Children;
Intestinal flora;
Nephrotic syndrome;
Butyrate
- From:
International Journal of Pediatrics
2025;52(5):295-298
- CountryChina
- Language:Chinese
-
Abstract:
The intestinal flora is a vast and complex microbial system，and its dysregulation may be associated with the occurrence and progression of various diseases.Nephrotic syndrome is a kidney disease characterized by massive proteinuria，hypoalbuminemia，edema，and hyperlipidemia.Some studies have found alterations in the intestinal flora of patients with nephrotic syndrome.Short-chain fatty acids produced by intestinal flora metabolism，particularly butyrate，may influence the occurrence and progression of nephrotic syndrome by regulating immune responses and inflammatory processes through their effects on the differentiation and function of regulatory T cells.These findings provide insights for exploring the pathophysiology of nephrotic syndrome and developing novel therapeutic strategies.
