Advances in nutrients involved in the regulation of children 's growth and development through DNA methylation
10.3760/cma.j.issn.1673-4408.2025.04.009
- VernacularTitle:营养素通过DNA甲基化调控儿童生长发育的研究进展
- Author:
Aikeremu KAISAIERJIANG
1
;
Nafeisha SHAMUXIDING
;
Mireguli MAIMAITI
Author Information
1. 新疆医科大学第一附属医院儿内四科，乌鲁木齐 830054
- Keywords:
Growth and development;
Nutrients;
DNA methylation;
One-carbon metabolism;
Epigenetics
- From:
International Journal of Pediatrics
2025;52(4):258-262
- CountryChina
- Language:Chinese
-
Abstract:
The growth and development of children is a complex and biological process influenced by a combination of factors such as genetics，environment，and nutrition. In recent years，DNA methylation，as a key epigenetic modification，has received widespread attention for its critical role in regulating gene expression and maintaining cellular functions. Nutrients affect DNA methylation through one-carbon metabolism and thereby mediate children 's growth and development in multiple aspects. This paper systematically reviews the topic，with a particular focus on the mechanisms of key nutrient intake during fetal and early childhood periods influencing life-long health and multigenerational effects. Additionally，the paper highlights the importance of individualized nutritional intervention. Based on the synthesis of multidisciplinary research findings，this review provides a reference for developing more effective public health strategies and personalized clinical intervention plans.
