Progress on the correlation between sepsis and chromogranin A with its derived peptides
10.3760/cma.j.issn.1673-4408.2025.04.008
- VernacularTitle:嗜铬粒蛋白A及其衍生肽与脓毒症的相关性研究进展
- Author:
Wei DANG
1
;
Wanyu FENG
;
Hua ZHU
;
Junli LI
Author Information
1. 内蒙古医科大学内蒙古临床医学院，呼和浩特 010020
- Keywords:
Children;
Sepsis;
Chromogranin A;
Derived peptides
- From:
International Journal of Pediatrics
2025;52(4):254-257
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection，characterized by high mortality rate.The pathological mechanisms of sepsis-induced organ failure are highly complex，including multiple processes such as abnormal immune responses，hemodynamic alterations，and severe endothelial dysfunction.Chromogranin A（Cg A），an acidic glycoprotein belonging to the granin family，serves as a precursor for various bioactive peptides，and is involved in diverse physiological processes，including inflammatory regulation，tissue repair，vascular function modulation，and glucose/lipid metabolism.Recent studies have revealed that Cg A and its derived peptides not only participate in the pathological progression of sepsis，but also exhibit significant correlations with the severity of organ injury. Consequently，Cg A has garnered attention for its potential role in the clinical diagnosis and prognostic evaluation of sepsis.This article provides a comprehensive review of the structure and functions of Cg A，as well as current research advances and clinical applications in sepsis.
