Progress on intestinal flora and functional constipation
10.3760/cma.j.issn.1673-4408.2025.04.006
- VernacularTitle:肠道菌群与功能性便秘的研究进展
- Author:
Jiajie WEI
1
;
Zhifeng LIU
Author Information
1. 南京医科大学附属儿童医院消化科 210008
- Keywords:
Functional constipation;
Intestinal flora;
Children;
Probiotics;
Fecal microbiota transplantation
- From:
International Journal of Pediatrics
2025;52(4):243-247
- CountryChina
- Language:Chinese
-
Abstract:
Functional constipation is a highly prevalent gastrointestinal disorder that can significantly impact the quality of life of affected children.The intestinal flora，known as normal microorganisms in the human gut，interacts with various systems to maintain intestinal stability.Recent evidence has increasingly highlighted a relationship between dysbiosis and functional constipation.Intestinal flora may not only regulate intestinal motility by influencing the enteric nervous system，but also secrete a variety of metabolites that stimulate intestinal chemoreceptors to enhance motility，although the exact mechanisms remain unclear.The treatment of functional constipation through the regulation of intestinal flora has been widely studied，primarily focusing on probiotics and fecal microbiota transplantation.This article reviews the research progress related to intestinal flora and functional constipation.
