Advances in treatment of refractory functional constipation in children
10.3760/cma.j.issn.1673-4408.2025.04.005
- VernacularTitle:儿童难治性功能性便秘治疗进展
- Author:
Xiaodan ZHANG
1
;
Lingfen XU
Author Information
1. 中国医科大学附属盛京医院小儿消化内科，沈阳 110004
- Keywords:
Children;
Functional constipation;
Refractory;
Treatment
- From:
International Journal of Pediatrics
2025;52(4):238-242
- CountryChina
- Language:Chinese
-
Abstract:
Functional constipation（FC）refers to constipation that is not caused by organic diseases of the intestines or systemic conditions，nor by medication-related factors. It is typically characterized by a prolonged course and a tendency for symptoms to recur. When constipation symptoms persist despite standardized treatment and significantly impact daily life，it may be termed refractory FC. In recent years，some novel treatment approaches for refractory FC have begun to be applied in children. These include new medications such as prucalopride，lubiprostone，and linaclotide，as well as fecal microbiota transplantation（FMT），neuromodulation，biofeedback therapy，and antegrade continence enema（ACE）. This article reviews the current advances in the treatment of refractory FC in children，aiming to provide insights and directions for the application of new therapeutic methods in clinical practice in the future.
