Progress on peripheral blood immunocytes in allergen immunotherapy
10.3760/cma.j.issn.1673-4408.2025.04.004
- VernacularTitle:外周血免疫细胞在变应原免疫治疗中的研究进展
- Author:
Zhenghong SONG
1
;
Jing HE
;
Shuxian LI
;
Zhimin CHEN
Author Information
1. 浙江大学医学院附属儿童医院呼吸科 国家儿童健康与疾病临床医学研究中心，杭州 310052
- Keywords:
Peripheral blood;
Immunocyte;
Allergen immunotherapy
- From:
International Journal of Pediatrics
2025;52(4):233-237
- CountryChina
- Language:Chinese
-
Abstract:
Allergen immunotherapy（AIT）can alter the natural course of allergic diseases through immunomodulatory mechanisms and maintain the efficacy after completion. The induction of immune tolerance by AIT is considered to be effective treatment and the mechanism involves the participation of a variety of immune cells，including effector T cells，B cells，dendritic cells，innate lymphoid cells，mast cells and basophils. Studies have found that a variety of immune cells in peripheral blood changed during AIT treatment and the changes of some immune cells were related to the efficacy of AIT，which may provide some theoretical reference for practical clinical activities and may become potential biomarkers for predicting and evaluating the efficacy of AIT. This article reviews the changes of peripheral blood immune cells in the treatment of AIT.
