Progress on the etiology of pediatric hypereosinophilia
10.3760/cma.j.issn.1673-4408.2025.04.002
- VernacularTitle:儿童高嗜酸性粒细胞增多症的病因学研究进展
- Author:
Long CHEN
1
;
Xiaowen ZHAI
Author Information
1. 国家儿童医学中心 复旦大学附属儿科医院血液科，上海 201102
- Keywords:
Child;
Hypereosinophilia;
Etiological factors;
Diagnostic approach
- From:
International Journal of Pediatrics
2025;52(4):223-227
- CountryChina
- Language:Chinese
-
Abstract:
Hypereosinophilia（HE）represents a group of clinical syndromes characterized by increased peripheral blood eosinophils.The etiology spectrum in pediatric patients differs significantly from adults，with secondary（reactive）HE being the most common type.In Chinese children，infections（especially parasitic infections）and allergic diseases are the predominant causes，accounting for approximately 40% and 35% of cases，respectively.Other common causes include immune-related diseases（about 15%）and hematologic neoplasms（about 5%）.Due to the physiological，cognitive，and expressive characteristics of children，identifying the underlying causes can be challenging.This review summarizes the major etiologies，clinical features，and recent advances in pediatric HE，aiming to help clinicians better understand and manage this condition.
