Progress on cytokines in bronchopulmonary dysplasia associated pulmonary hypertension
10.3760/cma.j.issn.1673-4408.2025.04.001
- VernacularTitle:细胞因子在支气管肺发育不良相关肺动脉高压中的研究进展
- Author:
Qianhan OUYANG
1
;
Cheng CAI
Author Information
1. 上海交通大学医学院附属儿童医院 上海市儿童医院新生儿科 200062
- Keywords:
Bronchopulmonary dysplasia;
Pulmonary hypertension;
Premature infant;
Cytokines
- From:
International Journal of Pediatrics
2025;52(4):217-222
- CountryChina
- Language:Chinese
-
Abstract:
Bronchopulmonary dysplasia（BPD）is a common lung disease in extremely premature infants.BPD-associated pulmonary hypertension（BPD-PH）is a pulmonary vascular disease induced by limited vessel growth and remodeling under the stimulation of early birth，inflammation exposure，and high oxygen exposure，et al.Studies have shown that inflammatory factors play a crucial role in the development of pulmonary vascular remodeling，and anti-inflammatory and immunosuppressive agents have been shown to improve BPD-PH，which may be applied in clinical practice to delay disease progression and treat the disease in the future.Cytokines，as key factors that initiate and regulate the body's immune response，are closely related to the pathogenesis of BPD-PH.Therefore，this review mainly explores the progress on the role of cytokines in the mechanism of BPD-PH.
