Progress on vitamin D in prevention and treatment of bronchopulmonary dysplasia in preterm infants
10.3760/cma.j.issn.1673-4408.2025.03.011
- VernacularTitle:维生素D防治早产儿支气管肺发育不良的研究进展
- Author:
Song LI
1
;
Dongzhui CHEN
;
Qiuyue ZHANG
Author Information
1. 海南医科大学第一临床医学院，海口 570100
- Keywords:
Bronchopulmonary dysplasia;
Premature infants;
Vitamin D;
Prevent;
Therapy
- From:
International Journal of Pediatrics
2025;52(3):194-198
- CountryChina
- Language:Chinese
-
Abstract:
Bronchopulmonary dysplasia（BPD）is a chronic respiratory disease characterized by developmental disorders and abnormal repair of lung tissue in premature infants.Its clinical manifestations are characterized by persistent respiratory distress syndrome，which can cause progressive lung function damage and significantly affect the quality of life and long-term prognosis of the affected children.Vitamin D has been proven to have multiple lung protective effects in recent years.It not only participates in regulating normal lung development，but also effectively inhibits inflammatory reactions，promotes the biosynthesis of pulmonary surfactant，regulates cell apoptosis，and maintains lung tissue function and structural integrity.The above physiological functions are significantly correlated with the pathophysiology of BPD，providing a new theoretical perspective for further elucidating the pathogenesis of BPD.Based on existing evidence，vitamin D may provide new treatment and research directions for BPD.
