Progress on bile acids and Clostridioides difficile infection
10.3760/cma.j.issn.1673-4408.2025.03.003
- VernacularTitle:胆汁酸与艰难梭菌感染研究进展
- Author:
Lewen TU
1
;
Xiaolu LI
;
Yizhong WANG
;
Ting ZHANG
Author Information
1. 上海市儿童医院 上海交通大学医学院附属儿童医院消化科 200062
- Keywords:
Bile acids;
Clostridioides difficile infection;
Antibiotics;
Fecal microbiota transplantation
- From:
International Journal of Pediatrics
2025;52(3):155-159
- CountryChina
- Language:Chinese
-
Abstract:
Clostridioides difficile infection（CDI）is a common cause of antibiotic-associated diarrhea，posing a significant burden on global healthcare systems.Clostridioides difficile（C.difficile）spreads through spores outside the body，germinates and grows into vegetative cells in the intestines，and releases toxins to cause disease.Bile acids are crucial metabolites in the gut，where primary and secondary bile acids play important roles throughout the lifecycle of C.difficile.This article reviews bile acids metabolism，their impact on C.difficile，and how they influence CDI treatment through antibiotics and fecal microbiota transplantation（FMT）.The aim is to provide new insights and reference for clinical management and research of CDI.
