Advances in the application of eosinophil-derived neurotoxin in allergic diseases
10.3760/cma.j.issn.1673-4408.2025.03.002
- VernacularTitle:嗜酸性粒细胞源性神经毒素在过敏性疾病中的应用进展
- Author:
Heting XIA
1
;
Nini DAI
;
Zailing LI
Author Information
1. 北京大学第三医院儿科 100191
- Keywords:
Eosinophil-derived neurotoxin;
Allergic diseases;
Biomarkers
- From:
International Journal of Pediatrics
2025;52(3):151-154
- CountryChina
- Language:Chinese
-
Abstract:
Eosinophil-derived neurotoxin（EDN）is an intracellular protein released during eosinophil activation，possessing ribonuclease activity.As a pivotal immunoregulatory molecule，EDN exerts significant influence on the immune response of the organism.Serving as a biomarker，it can reflect the activation state of eosinophils，providing robust support for the diagnosis and dynamic monitoring of allergic diseases.This article focuses on the application of EDN in various allergic diseases，including its effectiveness as a diagnostic tool，assessment of disease severity，and prognosis.By reviewing existing research findings，this review aims to provide references for further research and clinical practice in related fields.
