Advances in the treatment and prevention of asparaginase-associated pancreatitis
10.3760/cma.j.issn.1673-4408.2025.03.001
- VernacularTitle:门冬酰胺酶相关性胰腺炎的治疗和预防研究进展
- Author:
Huijiao TANG
1
;
Zhaohui DENG
Author Information
1. 上海交通大学医学院附属上海儿童医学中心消化内科 200127
- Keywords:
Asparaginase;
Pancreatitis;
Acute lymphoblastic leukemia;
Treatment;
Prevention
- From:
International Journal of Pediatrics
2025;52(3):145-150
- CountryChina
- Language:Chinese
-
Abstract:
Asparaginase plays a crucial role in the combined chemotherapy treatment for childhood haematological tumours.However，asparaginase-associated pancreatitis（AAP）is a major challenge for the continuation of asparaginase therapy，which seriously affects the chemotherapy process and results in a lower disease-free survival rate in children with haematological tumours.Currently，the pathogenesis of AAP is still unclear，and its treatment in the acute phase mainly includes nutritional support，fluid resuscitation，and drug therapy.There are no domestic and international guidelines for the prevention of AAP，and the reported preventive methods mainly include low-fat diets，octreotide，vitamin A，as well as galactose and pyruvate.Since prevention of AAP and effective treatment of AAP are important to ensure the safety and sequential application，this article reviews the treatment and prevention methods of AAP.
