Advances in metabolomics in sepsis
10.3760/cma.j.issn.1673-4408.2025.02.011
- VernacularTitle:脓毒症代谢组学研究进展
- Author:
Yue WANG
1
;
Hongjun MIAO
Author Information
1. 南京医科大学附属儿童医院急诊/重症医学科 210008
- Keywords:
Sepsis;
Metabolomics;
Biological sample
- From:
International Journal of Pediatrics
2025;52(2):122-126
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a life-threatening organ dysfunction caused by dysregulated host responses to infection，which is a main cause of death and critical illness globally.The metabolomics study of sepsis can most directly reflect the internal and external environmental changes in the body during sepsis，and can elucidate the most direct effects of disease or drugs on the human body at a specific time point.Currently，the research on sepsis-related metabolomics involves diverse biological samples，including blood，urine，feces，as well as specific cells and tissues.These biological samples each have their own advantages and limitations in metabolomics research.The common and unique metabolites among them suggest common metabolic pathways and specific metabolic pathways between different tissues.This paper reviews the metabolomics studies of sepsis in various biological samples，in order to provide new ideas for exploring the pathogenesis of sepsis，early identification and targeted therapies，as well as the selection of optimal samples for metabolomics research.
