Advances in treatment of atopic dermatitis in children by fecal microbiota transplantation
10.3760/cma.j.issn.1673-4408.2025.02.006
- VernacularTitle:肠道菌群移植治疗儿童特异性皮炎研究进展
- Author:
Hongyan LAN
1
;
Jie LI
;
Yanyan YU
Author Information
1. 南京医科大学附属苏州医院儿科 215000
- Keywords:
Children;
Fecal microbiota transplantation;
Atopic dermatitis;
Fecal microbiota dysbiosis
- From:
International Journal of Pediatrics
2025;52(2):98-101
- CountryChina
- Language:Chinese
-
Abstract:
Atopic dermatitis（AD）is a chronic，recurrent inflammatory skin disease.The pathogenesis of AD is complicated，involving many factors such as genetic，immune，and skin barrier.Previous studies have attributed skin barrier dysfunction to the changes in skin microbiota caused by immune disorders.In recent years，researchers have found that abnormal immune regulation related to the gut microbiota may be an important factor that leads to the development of AD.Gut microbiota dysbiosis and metabolomic disorders are of great significance to explore the pathogenesis of AD.The treatment of AD is currently focused on topical anti-inflammatory drugs，but the long-term efficacy is poor.Therefore，the treatment of fecal microbiota transplantation based on correcting gut microbiota dysbiosis came into being.This article summarized the current research status of gut microbiota dysbiosis in the occurrence and progression of AD，and the application progress and efficacy of fecal microbiota transplantation in children with AD，providing reference for the etiological analysis and clinical intervention of AD.
