Advances in pathogenesis of type 1 diabetes mellitus in children induced by COVID-19
10.3760/cma.j.issn.1673-4408.2025.02.004
- VernacularTitle:新型冠状病毒感染诱发儿童1型糖尿病致病机制研究进展
- Author:
Yong YANG
1
;
Dongmei SONG
Author Information
1. 乌兰察布市中心医院儿科 012000
- Keywords:
Children;
COVID-19;
Type 1 diabetes mellitus;
Autoimmunity;
Molecular mechanism
- From:
International Journal of Pediatrics
2025;52(2):88-92
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes is a disorder of the metabolism of sugar，fat and protein caused by the absolute or relative lack of insulin secretion.Type 1 diabetes mellitus（T1DM）is the most important type of childhood diabetes，and its etiological mechanism is complex.Genetic susceptibility and environmental factors are the main causes of its pathogenesis，and respiratory virus infection may be one of the environmental factors leading to T1DM.A large number of epidemiological studies have shown that during the novel coronavirus infection（COVID-19）pandemic，new cases of T1DM and diabetic ketoacidosis in children have increased significantly，suggesting that COVID-19 may be a predispose factor for T1DM in children.Based on the literature at home and abroad，this paper discusses the overview of childhood diabetes，epidemiological studies on COVID-19 and T1DM，and the pathogenesis of T1DM，so as to provide new strategies and ideas for the prevention，management and treatment of T1DM in children induced by COVID-19.
