Advances in diagnosis and treatment of hereditary dilated cardiomyopathy in children
10.3760/cma.j.issn.1673-4408.2025.02.002
- VernacularTitle:儿童遗传性扩张型心肌病诊治进展
- Author:
Xin LIN
1
;
Nari A
;
Yanyan HAN
Author Information
1. 吉林大学第一医院儿童医院小儿心血管科，长春 130000
- Keywords:
Child;
Dilated cardiomyopathy;
Genetics;
Clinical manifestation;
Treatment
- From:
International Journal of Pediatrics
2025;52(2):78-82
- CountryChina
- Language:Chinese
-
Abstract:
Dilated cardiomyopathy（DCM）is the most common type of cardiomyopathy in children.Gene mutation is one of the important causes of DCM in children.Gene mutations encoding sarcomeres，cytoskeleton，nuclear membrane proteins and ion channels lead to hereditary DCM.Hereditary DCM in children has a poor prognosis，and it is easy to be complicated with arrhythmia，has rapid deterioration of cardiac function and high rate of sudden cardiac death.Studies have found that some mutant genes have specific genetic patterns and clinical characteristics，and that the mutant genes have incomplete dominance and age-related dominance.This article discusses the clinical manifestations，auxiliary examinations and diagnosis of hereditary DCM in children through the relationship between gene and phenotype，and divides cardiomyopathy into stage A，stage B，stage C and stage D for treatment，guides follow-up，and suggests life and exercise methods，in order to provide reference for clinical work.
