Advances in the role of O-linked N-acetylglucosamine glycosylation in the pathogenesis of septic organ injury
10.3760/cma.j.issn.1673-4408.2025.01.007
- VernacularTitle:氧连-N-乙酰葡萄糖胺糖基化在脓毒症器官损伤发病机制中的作用研究进展
- Author:
Shuangshuang PENG
1
;
Hongjun MIAO
Author Information
1. 南京医科大学附属儿童医院急诊重症医学科 210008
- Keywords:
O-GlcNAcylation;
Sepsis;
Inflammatory reaction;
Multi-organ dysfunction syndrome
- From:
International Journal of Pediatrics
2025;52(1):33-37
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a life-threatening organ dysfunction caused by dysfunctional response to infection.Its key pathogenic links include immune damage and target organ involvement，which is a major cause of death in critically ill children.O-linked N-acetylglucosamine（O-GlcNAc）glycosylation，an important post-translational modification of proteins，influences various biological processes，including glucose metabolism，immune inflammatory response，and ferroptosis，by modifying specific proteins，thereby playing a role in the onset and progression of sepsis.Research indicates that O-GlcNAcylation has an important protective effect against organ injuries in the heart，brain，lungs，liver，and intestines during sepsis.However，the impact of this modification can vary depending on the target proteins and the cellular environment.From both the domestic and international perspective，this paper reviews the advances in O-GlcNAcylation in the pathogenesis of septic organ injury，aiming to offer new insights and strategies for the clinical management of sepsis.
