Progress on the effects of neonatal maternal separation and pain on human body and underlying mechanisms
10.3760/cma.j.issn.1673-4408.2024.12.005
- VernacularTitle:新生期母婴分离和疼痛对机体的影响及机制研究进展
- Author:
Tianfeng ZHONG
1
;
Jianwen YANG
;
Qijiang HU
;
Tao LIU
Author Information
1. 南昌大学第一附属医院儿科 330006
- Keywords:
Maternal separation;
Neonatal pain;
Neonate;
Model;
Neurobehavior
- From:
International Journal of Pediatrics
2024;51(12):814-818
- CountryChina
- Language:Chinese
-
Abstract:
In the neonatal intensive care unit（NICU），maternal separation（MS）and pain are identified as two of the most prevalent early stressors experienced by infants.These stressors have been demonstrated to result in a range of adverse effects on the developing infant，including but not limited to increased pain sensitivity，alterations in neuroplasticity，dysregulation of the endocrine system，immune response imbalance，as well as the emergence of anxiety and depression.To further elucidate their potential mechanisms，this paper presents a summary of recent animal models investigating neonatal MS and pain，while also reviews advancements in understanding how these early stressors impact organisms and their underlying mechanisms.The objective is to provide novel insights and scientific evidence with a view to prevent potential adverse outcomes for infants in the context of hospitalisation in the NICU.
