Development of Benchtop Low-Field Nuclear Magnetic Resonance Technology and Its Application in Drug Control Field
10.12116/j.issn.1004-5619.2024.340402
- VernacularTitle:台式低场核磁共振技术的发展及其在禁毒领域中的应用
- Author:
Qi LIAO
1
;
Yong-Hong LIU
;
Ying JIAO
;
Xiao-Ying YANG
;
Yi-Hua YANG
;
Cui-Mei LIU
;
Rui-Xia GAO
Author Information
1. 国家毒品实验室陕西分中心(陕西省公安厅毒品技术中心)陕西省毒品分析与毒情智慧监测研究重点实验室,陕西 西安 710115;西安交通大学化学学院,陕西 西安 710049
- Keywords:
forensic medicine;
toxicological analysis;
nuclear magnetic resonance;
low-field nuclear mag-netic resonance(LF-NMR);
benchtop NMR;
new psychoactive substance;
review
- From:
Journal of Forensic Medicine
2025;41(3):267-276
- CountryChina
- Language:Chinese
-
Abstract:
At present,the drug substitutes represented by new psychoactive substances are gradually be-coming popular,leading to an increasing demand for identifying novel drugs with unknown structures in drug investigation.Nuclear magnetic resonance(NMR)spectroscopy is an important tool for ana-lyzing molecular structures.In the absence of standard substances,quantitative NMR(qNMR)can un-dertake the quantitative analysis of target substances in complex mixtures and has unique advantages in the research of new drugs and their precursor drugs.Due to the limitations of the site and mainte-nance costs,as well as relatively complex operation,high-field superconducting NMR is less com-monly applied in drug research.The desktop low-field NMR developed in recent years provides a new alternative solution.Due to the use of permanent magnets,its size is reduced,and the operation and maintenance costs are lowered.It has been widely used in various research fields.This article reviews the development of low-field NMR technology,summarizes the application of desktop low-field NMR in screening and identification of suspicious substances,rapid content determination,analysis of drug manufacturing processes and synthetic routes,and correlation traceability.It also looks forward to the prospects and development directions of this technology in drug research,aiming to provide a reference for researchers who work in analytical chemistry and drug research.
