Application of Forensic Transcriptomics in the Identification of Tissue Origin of Body Fluid Stains

VernacularTitle:法医转录组学技术在体液斑迹组织来源推断中的应用
Author: Yi-Fan BAI ¹ ; He-Miao ZHAO ; Jing CHEN ; Hong-Di LIU ; Rui-Qin YANG ; Chong WANG
Author Information

1. 中国人民公安大学侦查学院,北京 100038;公安部鉴定中心法医遗传学公安部重点实验室,北京 100038
Keywords: forensic genetics; transcriptomics; body fluid stains; tissue origin identification; review
From: Journal of Forensic Medicine 2025;41(3):260-266
CountryChina
Language:Chinese
Abstract: The inference of tissue origin of body fluid stains is crucial for case investigation and court proceedings.However,traditional methods for identification of body fluid stains,such as morpho-logical,chemical,and immunoassay identifications have certain limitations,and there is an urgent need for more efficient methods for confirmatory experiments.In recent years,the rapid development of tran-scriptomics technology has provided new means for the identification of tissue origin of body fluid stains.Different types of RNA in the transcriptome have their own advantages.This paper elaborates in detail on the application of different types of RNA,such as mRNA,miRNA,circRNA,lncRNA,piRNA and microbial transcriptomics in body fluid identification,and summarizes their respective ad-vantages and limitations,in order to provide a reference for related research.