Identification of a Novel Synthetic Cathinone CMMP
10.12116/j.issn.1004-5619.2024.340103
- VernacularTitle:新型合成卡西酮类物质CMMP的检验
- Author:
Si-Yang HE
1
;
Qian-Ya DENG
;
Shui-Qing ZHENG
;
Chun-Fang NI
;
Wen-Juan SUN
;
Fang-Qi CAO
;
Chen LIANG
;
Fei-Jun GONG
Author Information
1. 上海市公安局物证鉴定中心 上海市现场物证重点实验室,上海 200083
- Keywords:
forensic medicine;
toxicological analysis;
new psychoactive substance(NPS);
synthetic cathinones;
2-methyl-1-[4-(methylthio)phenyl]-2-morpholinopropan-1-one(MTMP);
1-(4-chlorophe-nyl)-2-methyl-2-morpholinopropan-1-one(CMMP);
high resolution mass spectromet
- From:
Journal of Forensic Medicine
2024;40(6):550-556
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a method to identify an unknown substance based on the combined use of gas chromatography-quadrupole time-of-flight mass spectrometry(GC-QTOF-MS),ultra-high performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry(UPLC-Q/Orbitrap HRMS)and nuclear magnetic resonance(NMR)techniques.Methods The unknown substance was dissolved in methanol and was detected by GC-QTOF-MS and UPLC-Q/Orbitrap HRMS,and was dissolved in methanol-d4 to be detected by NMR.Results The main characteristics ion peaks of components with retention time of 9.67 min in GC-QTOF-MS measured were 84.080 8,110.999 7,128.107 0(base peak),138.994 7,etc.The protonated molecular ion peak m/z in UPLC-Q/Orbitrap HRMS was 268.109 3.It was inferred that the unknown substance was an analog of the syn-thetic cathinone substance 2-methyl-1-[4-(methylthio)phenyl]-2-morpholinopropan-1-one(MTMP)by comparing the mass spectrum information and molecular structure of MTMP.NMR analysis confirmed it as a novel N-morpholine substituted synthetic cathinone substance 1-(4-chlorophenyl)-2-methyl-2-morpholinopropan-1-one(CMMP).Conclusion The method established in this study can be used for structural confirmation of CMMP.
