Research Progress on the Application of MALDI-MSI in Hair Analysis
10.12116/j.issn.1004-5619.2024.340405
- VernacularTitle:MALDI-MSI技术用于毛发中毒(药)物分析的研究进展
- Author:
Jiao-Jiao JI
1
;
Xin WANG
;
Jia-Man LIN
;
Duo-Qi XU
;
Hui YAN
;
Min SHEN
Author Information
1. 中国刑事警察学院刑事科学技术学院,辽宁 沈阳 110854
- Keywords:
forensic medicine;
toxicological analysis;
matrix-assisted laser desorption ionization-mass spectrometry imaging(MALDI-MSI);
hair;
key technology;
data processing;
visualization;
review
- From:
Journal of Forensic Medicine
2024;40(6):542-549
- CountryChina
- Language:Chinese
-
Abstract:
Mass spectrometry imaging(MSI)is an emerging high-tech"photography"method combining mass spectrometry and image visualization technologies,which can simultaneously monitor the spatial distribution of multiple molecules in biological samples.In recent years,the characteristics of this tech-nology have been used to visually study the distribution of drugs in hair,among which matrix-assisted laser desorption ionization-mass spectrometry imaging(MALDI-MSI)technology has been most widely applied in hair analysis.Based on the principle of MALDI-MSI technology,this paper discusses the key technical elements of MALDI-MSI technology applied to hair analysis and reviews the research achievements of MSI in hair analysis.It concludes that improving the ionization efficiency,resolution,sensitivity and stability of MALDI-MSI technology remains the future exploration direction,and simpli-fying data analysis and establishing databases will help promote MALDI-MSI as a routine analytical technique for hair analysis.
