Research Progress on the Analysis of Anabolic Androgenic Steroids in Biological Samples Based on High Resolution Mass Spectrometry
10.12116/j.issn.1004-5619.2024.340705
- VernacularTitle:基于高分辨质谱技术的生物样本中蛋白同化雄性类固醇分析研究进展
- Author:
Zhen-Shuo GUO
1
;
Wen-Jia DUAN
;
Yu LIU
;
Yi-Ling TANG
;
Hui YAN
Author Information
1. 司法鉴定科学研究院 上海市法医学重点实验室 司法部司法鉴定重点实验室 上海市司法鉴定专业技术服务平台,上海 200063;昆明医科大学法医学院,云南 昆明 650500
- Keywords:
forensic medicine;
toxicological analysis;
high resolution mass spectrometry(HRMS);
ana-bolic androgenic steroid;
doping agent;
biological sample;
metabolite;
review
- From:
Journal of Forensic Medicine
2024;40(6):533-541
- CountryChina
- Language:Chinese
-
Abstract:
Anabolic androgenic steroids(AASs)are a class of synthetic steroid hormones that mimic androgens,and they rank as the most widely abused doping agents worldwide.High resolution mass spectrometry(HRMS)has unique advantages in the detection of AASs due to its high resolution,high sensitivity,high selectivity and data traceability.HRMS can not only be used for the qualitative and quantitative analysis of AASs and their metabolites in different biological samples,effectively improving the ability to analyze complex samples and increasing the reliability of analytical results,but can also infer AASs metabolites and reveal metabolic pathways by combining in vitro and in vivo metabolic models.This paper reviews the research progress of HRMS in AASs analysis methods,in vitro and in vivo metabolism of AASs,and also explores its application prospects in the field of forensic science.
