Progress in Bacterial Plasmid Active Segregation Systems
10.19756/j.issn.0253-3820.251256
- VernacularTitle:细菌中质粒主动分配系统的研究进展
- Author:
Jing-Jing ZHAO
1
;
Wei-Ming TIAN
;
Wei-Li XU
;
Xiao-Jun HAN
Author Information
1. 哈尔滨工业大学化工与化学学院,城乡水资源与水环境全国重点实验室,黑龙江省分子科学联合实验室(国际合作),哈尔滨 150001
- Keywords:
Bacterial plasmid segregation system;
ParABS system;
ParMRC system;
TubZRC system;
Review
- From:
Chinese Journal of Analytical Chemistry
2025;53(11):1773-1783
- CountryChina
- Language:Chinese
-
Abstract:
The faithful segregation of genetic material to daughter cells is a fundamental biological process and a prerequisite for autonomous construction of robustly self-replicating artificial cells.Artificial cells are mimic cell structures with part or whole functions of normal cells.The complexity of eukaryotic chromosome segregation machinery has limited its applications in the field of synthetic biology.In contrast,the plasmid segregation machineries employed by prokaryotes are relatively simple and can provide valuable approaches for the bottom-up construction of complex artificial cells.This review aimed to comprehensively analyze the origin species and working mechanism of three bacterial plasmid segregation systems,namely ParABS,ParMRC,and TubZRC systems.The current researches on plasmid segregation both in bacterial and artificial cellular systems were summarized,and the future directions of this field were also proposed.
