Construction of Colchicine Molecularly Imprinted Polymer and Its Application in Blood Sample Analysis
10.19756/j.issn.0253-3820.251097
- VernacularTitle:秋水仙碱分子印迹聚合物的构建及在血样分析中的应用
- Author:
Ying ZHANG
1
;
Yuan-Yuan JIANG
;
Zheng SUN
;
Kai-Han WU
;
Juan-Na WEI
;
Hui XU
Author Information
1. 法庭毒物分析公安部重点实验室(北京市公安局),北京 100192
- Keywords:
Colchicine;
Molecularly imprinted polymer;
Selective adsorption;
Plasma pre-treatment
- From:
Chinese Journal of Analytical Chemistry
2025;53(10):1741-1750
- CountryChina
- Language:Chinese
-
Abstract:
Molecularly imprinted polymers(MIPs)of colchicine(COL)were prepared by precipitation polymerization with COL as template,methacrylic acid(MAA)as monomer,ethylene glycol dimethacrylate(EGDMA)as crosslinking agent,azobisisobutyronitrile(AIBN)as initiator and chloroform as porogen.The basic structure of the prepared MIPs was characterized by scanning electron microscopy(SEM),transmission electron microscopy(TEM)and Fourier transform infrared(FT-IR)spectrometry,and the adsorption properties of MIPs were evaluated by kinetic adsorption,isothermal adsorption and selective adsorption experiments.The results indicated that the prepared MIPs had uniform particles size,with a maximum adsorption capacity of 62.61 mg/g for COL and an imprinting factor of 3.74,and was suitable for sample pretreatment in determination of COL blood concentration,enabling the enrichment and separation of trace or even ultra-trace target components,thereby improving analytical capabilities.
