Advances in Construction and Application of Multi-channel and Multi-mode Fluorescent Probes in Recognition of Biothiols Molecules
10.19756/j.issn.0253-3820.241018
- VernacularTitle:多通道、多模式识别生物硫醇荧光探针分子的构建及其应用研究进展
- Author:
Hong-Peng ZHANG
1
;
Xiao-Meng JIAO
;
Yang ZHANG
;
Jing LIU
;
Yin-Juan BAI
Author Information
1. 西北大学化学与材料科学学院,合成与天然功能分子教育部重点实验室,西安 710127
- Keywords:
Biothiols;
Fluorescent probe;
Multi-channel;
Multi-mode;
Review
- From:
Chinese Journal of Analytical Chemistry
2025;53(8):1226-1237,中插1-中插3
- CountryChina
- Language:Chinese
-
Abstract:
Biothiols are a kind of bioactive substances which play an important role in maintaining normal metabolism and intracellular redox homeostasis of living system.The detection of biothiols has important guiding significance in study of physiological process and disease diagnosis.Among many biothiols detection methods,fluorescence probe method has become one of the widely used methods for detection of biothiols because of its advantages such as high sensitivity,good selectivity,non-invasiveness and convenience.The fluorescence probe method can realize single identification of one kind of biothiols and multi-channel identification of many kinds of biothiols.Meanwhile,fluorescence probe method can also cooperate with naked-eye visual detection,photoacoustic detection,ultraviolet-visible spectroscopy detection and other modes to achieve multi-mode recognition of biothiols.In this paper,the recent research progress on fluorescent probes in the field of multi-channel and multi-mode recognition of biothiols was reviewed,and its design strategy,detection mode,detection signal and application in biological detection were summarized.The development of multi-channel and multi-mode detection of biothiols was also prospected.
